Production of Wilson Disease Model Rabbits with Homology-Directed Precision Point Mutations in the ATP7B Gene Using the CRISPR/Cas9 System

CRISPR/Cas9 has recently been developed as an efficient genome engineering tool. The rabbit is a suitable animal model for studies of metabolic diseases. In this study, we generated ATP7B site-directed point mutation rabbits to simulate a major mutation type in Asians (p. Arg778Leu) with Wilson dise...

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Vydáno v:Sci Rep
Hlavní autoři: Jiang, Weihua, Liu, Lili, Chang, Qiurong, Xing, Fengying, Ma, Zhengwen, Fang, Zhenfu, Zhou, Jing, Fu, Li, Wang, Huiyang, Huang, Xingxu, Chen, Xuejin, Li, Yao, Li, Shangang
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5778067/
https://ncbi.nlm.nih.gov/pubmed/29358698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19774-4
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