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GGA2 interacts with EGFR cytoplasmic domain to stabilize the receptor expression and promote cell growth

Epidermal growth factor receptor (EGFR) signaling and its downregulation upon ligand binding have been extensively documented. However, the mechanisms by which cells maintain steady-state EGFR expression remain poorly understood. Here, we report a novel role of Golgi-localized, γ-adaptin ear-contain...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Uemura, Takefumi, Kametaka, Satoshi, Waguri, Satoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5778047/
https://ncbi.nlm.nih.gov/pubmed/29358589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19542-4
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