Defective STIM-mediated store operated Ca(2+) entry in hepatocytes leads to metabolic dysfunction in obesity

Defective Ca(2+) handling is a key mechanism underlying hepatic endoplasmic reticulum (ER) dysfunction in obesity. ER Ca(2+) level is in part monitored by the store-operated Ca(2+) entry (SOCE) system, an adaptive mechanism that senses ER luminal Ca(2+) concentrations through the STIM proteins and f...

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Pubblicato in:eLife
Autori principali: Arruda, Ana Paula, Pers, Benedicte Mengel, Parlakgul, Günes, Güney, Ekin, Goh, Ted, Cagampan, Erika, Lee, Grace Yankun, Goncalves, Renata L, Hotamisligil, Gökhan S
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2017
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777820/
https://ncbi.nlm.nih.gov/pubmed/29243589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29968
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