Tumor exome sequencing and copy number alterations reveal potential predictors of intrinsic resistance to multi-targeted tyrosine kinase inhibitors

Multi-targeted tyrosine kinase inhibitors (TKIs) have broad efficacy and similar FDA-approved indications, suggesting shared molecular drug targets across cancer types. Irrespective of tumor type, 20-30% of patients treated with multi-targeted TKIs demonstrate intrinsic resistance, with progressive...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Gillis, Nancy K., Rotroff, Daniel M., Mesa, Tania E., Yao, Jiqiang, Chen, Zhihua, Carulli, Michael A., Yoder, Sean J., Walko, Christine M., Teer, Jamie K., McLeod, Howard L.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777758/
https://ncbi.nlm.nih.gov/pubmed/29383146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22914
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