Vascular CXCR4 limits atherosclerosis by maintaining arterial integrity: evidence from mouse and human studies

BACKGROUND: The CXCL12/CXCR4 chemokine ligand/receptor axis controls (progenitor) cell homeostasis and trafficking. So far, an atheroprotective role of CXCL12/CXCR4 has only been implied through pharmacological intervention, particularly as the somatic deletion of the CXCR4 gene in mice is embryonic...

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Udgivet i:Circulation
Main Authors: Döring, Yvonne, Noels, Heidi, van der Vorst, Emiel P.C., Neideck, Carlos, Egea, Virginia, Drechsler, Maik, Mandl, Manuela, Pawig, Lukas, Jansen, Yvonne, Schröder, Katrin, Bidzhekov, Kiril, Megens, Remco T.A., Theelen, Wendy, Klinkhammer, Barbara M., Boor, Peter, Schurgers, Leon, van Gorp, Rick, Ries, Christian, Kusters, Pascal J.H., van der Wal, Allard, Hackeng, Tilman M., Gäbel, Gabor, Brandes, Ralf P., Soehnlein, Oliver, Lutgens, Esther, Vestweber, Dietmar, Teupser, Daniel, Holdt, Lesca M., Rader, Daniel J., Saleheen, Danish, Weber, Christian
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777319/
https://ncbi.nlm.nih.gov/pubmed/28450349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.117.027646
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