Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies

BACKGROUND: Paracetamol overdose is common but patient stratification is suboptimal. We investigated the usefulness of new biomarkers that have either enhanced liver specificity (microRNA-122 [miR-122]) or provide mechanistic insights (keratin-18 [K18], high mobility group box-1 [HMGB1], and glutama...

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Publicado en:Lancet Gastroenterol Hepatol
Main Authors: Dear, James W, Clarke, Joanna I, Francis, Ben, Allen, Lowri, Wraight, Jonathan, Shen, Jasmine, Dargan, Paul I, Wood, David, Cooper, Jamie, Thomas, Simon H L, Jorgensen, Andrea L, Pirmohamed, Munir, Park, B Kevin, Antoine, Daniel J
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier B.V 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777094/
https://ncbi.nlm.nih.gov/pubmed/29146439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S2468-1253(17)30266-2
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