Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA

Coronaviruses (CoVs) stand out among RNA viruses because of their unusually large genomes (∼30 kb) associated with low mutation rates. CoVs code for nsp14, a bifunctional enzyme carrying RNA cap guanine N7-methyltransferase (MTase) and 3′-5′ exoribonuclease (ExoN) activities. ExoN excises nucleotide...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Ferron, François, Subissi, Lorenzo, Silveira De Morais, Ana Theresa, Le, Nhung Thi Tuyet, Sevajol, Marion, Gluais, Laure, Decroly, Etienne, Vonrhein, Clemens, Bricogne, Gérard, Canard, Bruno, Imbert, Isabelle
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777078/
https://ncbi.nlm.nih.gov/pubmed/29279395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718806115
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