Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor

Programmed cell death-1 (PD-1) is an essential inhibitory receptor in T cells. Antibodies targeting PD-1 elicit durable clinical responses in patients with multiple tumor indications. Nevertheless, a significant proportion of patients do not respond to anti–PD-1 treatment, and a better understanding...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Peled, Michael, Tocheva, Anna S., Sandigursky, Sabina, Nayak, Shruti, Philips, Elliot A., Nichols, Kim E., Strazza, Marianne, Azoulay-Alfaguter, Inbar, Askenazi, Manor, Neel, Benjamin G., Pelzek, Adam J., Ueberheide, Beatrix, Mor, Adam
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776966/
https://ncbi.nlm.nih.gov/pubmed/29282323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710437115
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