α7-Nicotinic Acetylcholine Receptor Agonist Ameliorates Nicotine Plus High-Fat Diet–Induced Hepatic Steatosis in Male Mice by Inhibiting Oxidative Stress and Stimulating AMPK Signaling

α7-Nicotinic acetylcholine receptor (α7nAChR) agonists confer protection against a wide variety of cytotoxic insults and suppress oxidative stress and apoptosis in various cell systems, including hepatocytes. We recently demonstrated that nicotine, when combined with a high-fat diet (HFD), triggers...

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Publié dans:Endocrinology
Auteurs principaux: Hasan, Mohammad Kamrul, Friedman, Theodore C., Sims, Carl, Lee, Desean L., Espinoza-Derout, Jorge, Ume, Adaku, Chalfant, Victor, Lee, Martin L., Sinha-Hikim, Indrani, Lutfy, Kabirullah, Liu, Yanjun, Mahata, Sushil K., Sinha-Hikim, Amiya P.
Format: Artigo
Langue:Inglês
Publié: Endocrine Society 2017
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776480/
https://ncbi.nlm.nih.gov/pubmed/29272360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2017-00594
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