Histone demethylase PHF8 regulates hypoxia signaling through HIF1α and H3K4me3

Hypoxia through transcription factor HIF1α plays a critical role in cancer development. In prostate cancer, HIF1α interplays with androgen receptor (AR) to contribute to the progression of this disease to its lethal form—castration-resistant prostate cancer (CRPC). Hypoxia upregulates several epigen...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta Gene Regul Mech
Main Authors: Maina, Peterson Kariuki, Shao, Peng, Jia, Xiongfei, Liu, Qi, Umesalma, Shaikamjad, Marin, Maximo, Long, Donald, Concepción-Román, Samantha, Qi, Hank Heng
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776039/
https://ncbi.nlm.nih.gov/pubmed/28734980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagrm.2017.07.005
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