Double-stranded RNA released from damaged articular chondrocytes promotes cartilage degeneration via Toll-like receptor 3-interleukin-33 pathway

Pattern recognition receptors (PRRs), including Toll-like receptor 3 (TLR3), are involved in arthritic responses; however, whether interleukin-33 (IL-33) is involved in TLR3-mediated cartilage degeneration is unknown. Here, we found that IL-33 was abundantly increased in chondrocytes of osteoarthrit...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Li, Changwei, Chen, Kaizhe, Kang, Hui, Yan, Yufei, Liu, Kewei, Guo, Changjun, Qi, Jin, Yang, Kai, Wang, Fei, Guo, Lei, He, Chuan, Deng, Lianfu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5775407/
https://ncbi.nlm.nih.gov/pubmed/29095435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.534
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