Metformin ameliorates arsenic trioxide hepatotoxicity via inhibiting mitochondrial complex I

Arsenic trioxide (ATO) is a well-accepted chemotherapy agent in managing promyelocytic leukemia. ATO often causes severe health hazards such as hepatotoxicity, dermatosis, neurotoxicity, nephrotoxicity and cardiotoxicity. The production of reactive oxygen species, (ROS) play a significant role in AT...

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Detalles Bibliográficos
Publicado en:Cell Death Dis
Autores principales: Ling, Sunbin, Shan, Qiaonan, Liu, Peng, Feng, Tingting, Zhang, Xuanyu, Xiang, Penghui, Chen, Kangchen, Xie, Haiyang, Song, Penghong, Zhou, Lin, Liu, Jimin, Zheng, Shusen, Xu, Xiao
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2017
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5775401/
https://ncbi.nlm.nih.gov/pubmed/29095437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.482
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