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Robust phenotype prediction from gene expression data using differential shrinkage of co-regulated genes

Discovery of robust diagnostic or prognostic biomarkers is a key to optimizing therapeutic benefit for select patient cohorts - an idea commonly referred to as precision medicine. Most discovery studies to derive such markers from high-dimensional transcriptomics datasets are weakly powered with sam...

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Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: Zarringhalam, Kourosh, Degras, David, Brockel, Christoph, Ziemek, Daniel
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5775343/
https://ncbi.nlm.nih.gov/pubmed/29352257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19635-0
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