High Antigen Dose Is Detrimental to Post-Exposure Vaccine Protection against Tuberculosis

Mycobacterium tuberculosis (Mtb), the etiologic agent of tuberculosis (TB), causes 1.8M deaths annually. The current vaccine, BCG, has failed to eradicate TB leaving 25% of the world’s population with latent Mtb infection (LTBI), and 5–10% of these people will reactivate and develop active TB. An ef...

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Bibliographische Detailangaben
Veröffentlicht in:Front Immunol
Hauptverfasser: Billeskov, Rolf, Lindenstrøm, Thomas, Woodworth, Joshua, Vilaplana, Cristina, Cardona, Pere-Joan, Cassidy, Joseph P., Mortensen, Rasmus, Agger, Else Marie, Andersen, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5775287/
https://ncbi.nlm.nih.gov/pubmed/29379507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01973
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