Truncating the gp41 Cytoplasmic Tail of Simian Immunodeficiency Virus Decreases Sensitivity to Neutralizing Antibodies without Increasing the Envelope Content of Virions

An incomplete understanding of native human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) envelope glycoproteins (Envs) impedes the development of structural models of Env and vaccine design. This shortcoming is due in part to the low number of Env trimers on virus particles....

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: White, Ellen, Wu, Fan, Chertova, Elena, Bess, Julian, Roser, James D., Lifson, Jeffrey D., Hirsch, Vanessa M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2018
Assuntos:
Pathogenesis and Immunity
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774881/
https://ncbi.nlm.nih.gov/pubmed/29142124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01688-17
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