Doxycycline modulates VEGF-A expression: Failure of doxycycline-inducible lentivirus shRNA vector to knockdown VEGF-A expression in transgenic mice

Vascular endothelial growth factor-A (VEGF-A) is the master regulator of angiogenesis, vascular permeability and growth. However, its role in mature blood vessels is still not well understood. To better understand the role of VEGF-A in the adult vasculature, we generated a VEGF-A knockdown mouse mod...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Merentie, Mari, Rissanen, Riina, Lottonen-Raikaslehto, Line, Huusko, Jenni, Gurzeler, Erika, Turunen, Mikko P., Holappa, Lari, Mäkinen, Petri, Ylä-Herttuala, Seppo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774698/
https://ncbi.nlm.nih.gov/pubmed/29351307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0190981
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