In situ characterization of advanced glycation end products (AGEs) in collagen and model extracellular matrix by solid state NMR

Non-enzymatic glycation of extracellular matrix with (U-(13)C(5))-d-ribose-5-phosphate (R5P), enables in situ 2D ssNMR identification of many deleterious protein modifications and crosslinks, including previously unreported oxalamido and hemiaminal (CH(3)–CH(OH)NHR) substructures. Changes in charged...

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Udgivet i:Chem Commun (Camb)
Main Authors: Li, R., Rajan, R., Wong, W. C. V., Reid, D. G., Duer, M. J., Somovilla, V. J., Martinez-Saez, N., Bernardes, G. J. L., Hayward, R., Shanahan, C. M.
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2017
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774432/
https://ncbi.nlm.nih.gov/pubmed/29192920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7cc06624d
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