Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis

In addition to motor neurone degeneration, up to 50% of amyotrophic lateral sclerosis (ALS) patients present with cognitive decline. Understanding the neurobiological changes underlying these cognitive deficits is critical, as cognitively impaired patients exhibit a shorter survival time from sympto...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Henstridge, Christopher M., Sideris, Dimitrios I., Carroll, Emily, Rotariu, Sanziana, Salomonsson, Sally, Tzioras, Makis, McKenzie, Chris-Anne, Smith, Colin, von Arnim, Christine A. F., Ludolph, Albert C., Lulé, Dorothée, Leighton, Danielle, Warner, Jon, Cleary, Elaine, Newton, Judith, Swingler, Robert, Chandran, Siddharthan, Gillingwater, Thomas H., Abrahams, Sharon, Spires-Jones, Tara L.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2017
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773656/
https://ncbi.nlm.nih.gov/pubmed/29273900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-017-1797-4
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