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Dynamic all-optical drug screening on cardiac voltage-gated ion channels
Voltage-gated ion channels (VGCs) are prime targets for the pharmaceutical industry, but drug profiling on VGCs is challenging, since drug interactions are confined to specific conformational channel states mediated by changes in transmembrane potential. Here we combined various optogenetic tools to...
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| 出版年: | Sci Rep |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5773578/ https://ncbi.nlm.nih.gov/pubmed/29348631 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19412-z |
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