Intradermal delivery of STAT3 siRNA to treat melanoma via dissolving microneedles

Hyperactivity of signal transducer and activity of transcription 3 (STAT3) plays a crucial role in melanoma invasion and metastasis. Gene therapy applying siRNA targeting STAT3 is a potential therapeutic strategy for melanoma. In this article, we first fabricated safe and novel dissolving microneedl...

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Udgivet i:Sci Rep
Main Authors: Pan, Jingtong, Ruan, Wenyi, Qin, Mengyao, Long, Yueming, Wan, Tao, Yu, Kaiyue, Zhai, Yuanhao, Wu, Chuanbin, Xu, Yuehong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773564/
https://ncbi.nlm.nih.gov/pubmed/29348670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19463-2
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