Evaluation of mitochondrial bioenergetics, dynamics, endoplasmic reticulum-mitochondria crosstalk, and reactive oxygen species in fibroblasts from patients with complex I deficiency

Mitochondrial complex I (CI) deficiency is the most frequent cause of oxidative phosphorylation (OXPHOS) disorders in humans. In order to benchmark the effects of CI deficiency on mitochondrial bioenergetics and dynamics, respiratory chain (RC) and endoplasmic reticulum (ER)-mitochondria communicati...

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Pubblicato in:Sci Rep
Autori principali: Leipnitz, Guilhian, Mohsen, Al-Walid, Karunanidhi, Anuradha, Seminotti, Bianca, Roginskaya, Vera Y., Markantone, Desiree M., Grings, Mateus, Mihalik, Stephanie J., Wipf, Peter, Van Houten, Bennett, Vockley, Jerry
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773529/
https://ncbi.nlm.nih.gov/pubmed/29348607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19543-3
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