High response rate to PD-1 blockade in desmoplastic melanomas

Desmoplastic melanoma (DM) is a rare subtype of melanoma characterized by dense fibrous stroma, resistance to chemotherapy and a lack of actionable driver mutations, but is highly associated with ultraviolet light DNA damage.(1) We analysed 60 patients with advanced DM treated with programmed cell d...

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Bibliografiska uppgifter
I publikationen:Nature
Huvudupphovsmän: Eroglu, Zeynep, Zaretsky, Jesse M., Hu-Lieskovan, Siwen, Kim, Dae Won, Algazi, Alain, Johnson, Douglas B., Liniker, Elizabeth, Kong, Ben, Munhoz, Rodrigo, Rapisuwon, Suthee, Gherardini, Pier Federico, Chmielowski, Bartosz, Wang, Xiaoyan, Shintaku, I. Peter, Wei, Cody, Sosman, Jeffrey A., Joseph, Richard, Postow, Michael A., Carlino, Matteo S, Hwu, Wen-Jen, Scolyer, Richard A., Messina, Jane, Cochran, Alistair J., Long, Georgina V., Ribas, Antoni
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773412/
https://ncbi.nlm.nih.gov/pubmed/29320474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature25187
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