Incorporation of iloprost in phospholipase-resistant phospholipid scaffold enhances its barrier protective effects on pulmonary endothelium

Correction of barrier dysfunction and inflammation in acute lung injury (ALI) represents an important problem. Previous studies demonstrate barrier-protective and anti-inflammatory effects of bioactive lipid prostacyclin and its stable analog iloprost (ILO). We generated a phospholipase resistant sy...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Oskolkova, Olga, Sarich, Nicolene, Tian, Yufeng, Gawlak, Grzegorz, Meng, Fanyong, Bochkov, Valery N., Berdyshev, Evgeny, Birukova, Anna A., Birukov, Konstantin G.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772615/
https://ncbi.nlm.nih.gov/pubmed/29343759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19197-1
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