Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease

Hypoxia-inducible factors (HIFs) are key elements for controlling immune cell metabolism and functions. While HIFs are known to be involved in T cells and macrophages activation, their functions in B lymphocytes are poorly defined. Here, we show that hypoxia-inducible factor-1α (HIF-1α) contributes...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Meng, Xianyi, Grötsch, Bettina, Luo, Yubin, Knaup, Karl Xaver, Wiesener, Michael Sean, Chen, Xiao-Xiang, Jantsch, Jonathan, Fillatreau, Simon, Schett, Georg, Bozec, Aline
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772476/
https://ncbi.nlm.nih.gov/pubmed/29343683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02683-x
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