Impact of tissue kinetic heterogeneity on PET quantification: case study with the L-[1-(11)C]leucine PET method for cerebral protein synthesis rates

Functional quantification with PET is generally based on modeling that assumes tissue regions are kinetically homogeneous. Even in regions sufficiently small to approach homogeneity, spillover due to resolution limitations of PET scanners may introduce heterogeneous kinetics into measured data. Here...

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Udgivet i:Sci Rep
Main Authors: Veronese, Mattia, Bertoldo, Alessandra, Tomasi, Giampaolo, Smith, Carolyn Beebe, Schmidt, Kathleen C.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772379/
https://ncbi.nlm.nih.gov/pubmed/29343731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18890-x
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