Subcellular Genomics: Pervasive within-mitochondrion SNV heteroplasmy revealed by single mitochondrion sequencing

A number of mitochondrial diseases arise from Single Nucleotide Variant (SNV) accumulation in multiple mitochondria. Here we present a method for identification of variants present at the single mitochondrion level in individual mouse and human neuronal cells allowing for extremely high resolution s...

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Udgivet i:Cell Rep
Main Authors: Morris, Jacqueline, Na, Young-Ji, Zhu, Hua, Lee, Jae-Hee, Giang, Hoa, Ulyanova, Alexandra V., Baltuch, Gordon H., Brem, Steven, Chen, H. Isaac, Kung, David K., Lucas, Timothy H., O’Rourke, Donald M., Wolf, John A., Grady, M. Sean, Sul, Jai-Yoon, Kim, Junhyong, Eberwine, James
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771502/
https://ncbi.nlm.nih.gov/pubmed/29212019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.11.031
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