Ketone body 3‐hydroxybutyrate mimics calorie restriction via the Nrf2 activator, fumarate, in the retina

Calorie restriction (CR) being the most robust dietary intervention provides various health benefits. D‐3‐hydroxybutyrate (3HB), a major physiological ketone, has been proposed as an important endogenous molecule for CR. To investigate the role of 3HB in CR, we investigated potential shared mechanis...

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Bibliografske podrobnosti
izdano v:Aging Cell
Main Authors: Izuta, Yusuke, Imada, Toshihiro, Hisamura, Ryuji, Oonishi, Erina, Nakamura, Shigeru, Inagaki, Emi, Ito, Masataka, Soga, Tomoyoshi, Tsubota, Kazuo
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770878/
https://ncbi.nlm.nih.gov/pubmed/29119686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12699
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