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Ca(2+) releases E‐Syt1 autoinhibition to couple ER‐plasma membrane tethering with lipid transport
The extended synaptotagmins (E‐Syts) are endoplasmic reticulum (ER) proteins that bind the plasma membrane (PM) via C2 domains and transport lipids between them via SMP domains. E‐Syt1 tethers and transports lipids in a Ca(2+)‐dependent manner, but the role of Ca(2+) in this regulation is unclear. O...
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| Izdano u: | EMBO J |
|---|---|
| Glavni autori: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
John Wiley and Sons Inc.
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5770786/ https://ncbi.nlm.nih.gov/pubmed/29222176 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201797359 |
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