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Ca(2+) releases E‐Syt1 autoinhibition to couple ER‐plasma membrane tethering with lipid transport

The extended synaptotagmins (E‐Syts) are endoplasmic reticulum (ER) proteins that bind the plasma membrane (PM) via C2 domains and transport lipids between them via SMP domains. E‐Syt1 tethers and transports lipids in a Ca(2+)‐dependent manner, but the role of Ca(2+) in this regulation is unclear. O...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:EMBO J
Main Authors: Bian, Xin, Saheki, Yasunori, De Camilli, Pietro
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770786/
https://ncbi.nlm.nih.gov/pubmed/29222176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201797359
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