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Role of Macromolecular Crowding on the Intracellular Diffusion of DNA Binding Proteins

Recent experiments suggest that cellular crowding facilitates the target search dynamics of proteins on DNA, the mechanism of which is not yet known. By using large scale computer simulations, we show that two competing factors, namely the width of the depletion layer that separates the crowder clou...

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Vydáno v:Sci Rep
Hlavní autoři: Dey, Pinki, Bhattacherjee, Arnab
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770392/
https://ncbi.nlm.nih.gov/pubmed/29339733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18933-3
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