Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

Pancreatic ductal adenocarcinomas (PDAC) are highly metastatic with poor prognosis, mainly due to delayed detection. We hypothesized that intercellular communication is critical for metastatic progression. Here, we show that PDAC- derived exosomes induce liver pre-metastatic niche formation in naïve...

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Publicado en:Nat Cell Biol
Main Authors: Costa-Silva, Bruno, Aiello, Nicole M., Ocean, Allyson J., Singh, Swarnima, Zhang, Haiying, Thakur, Basant Kumar, Becker, Annette, Hoshino, Ayuko, Mark, Milica Tešić, Molina, Henrik, Xiang, Jenny, Zhang, Tuo, Theilen, Till-Martin, García-Santos, Guillermo, Williams, Caitlin, Ararso, Yonathan, Huang, Yujie, Rodrigues, Gonçalo, Shen, Tang-Long, Labori, Knut Jørgen, Lothe, Inger Marie Bowitz, Kure, Elin H., Hernandez, Jonathan, Doussot, Alexandre, Ebbesen, Saya H., Grandgenett, Paul M., Hollingsworth, Michael A., Jain, Maneesh, Mallya, Kavita, Batra, Surinder K., Jarnagin, William R., Schwartz, Robert E., Matei, Irina, Peinado, Héctor, Stanger, Ben Z., Bromberg, Jacqueline, Lyden, David C.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5769922/
https://ncbi.nlm.nih.gov/pubmed/25985394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3169
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