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HIV-1 NC-induced stress granule assembly and translation arrest are inhibited by the dsRNA binding protein Staufen1

The nucleocapsid (NC) is an N-terminal protein derived from the HIV-1 Gag precursor polyprotein, pr55(Gag). NC possesses key functions at several pivotal stages of viral replication. For example, an interaction between NC and the host double-stranded RNA-binding protein Staufen1 was shown to regulat...

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Detalhes bibliográficos
Publicado no:RNA
Main Authors: Rao, Shringar, Cinti, Alessandro, Temzi, Abdelkrim, Amorim, Raquel, You, Ji Chang, Mouland, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5769749/
https://ncbi.nlm.nih.gov/pubmed/29127210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.064618.117
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