Systemic HIV-1 infection produces a unique glial footprint in humanized mouse brains

Studies of innate glial cell responses for progressive human immunodeficiency virus type one (HIV-1) infection are limited by a dearth of human disease-relevant small-animal models. To overcome this obstacle, newborn NOD/SCID/IL2Rγc(−/−) (NSG) mice were reconstituted with a humanized brain and immun...

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Bibliographic Details
Published in:Dis Model Mech
Main Authors: Li, Weizhe, Gorantla, Santhi, Gendelman, Howard E., Poluektova, Larisa Y.
Format: Artigo
Language:Inglês
Published: The Company of Biologists Ltd 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5769612/
https://ncbi.nlm.nih.gov/pubmed/29084769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.031773
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