TET2 Loss Dysregulates the Behavior of Bone Marrow Mesenchymal Stromal Cells and Accelerates Tet2(−/−)-Driven Myeloid Malignancy Progression

TET2 is a methylcytosine dioxygenase that regulates cytosine hydroxymethylation. Although there are extensive data implicating a pivotal role of TET2 in hematopoietic stem/progenitor cells (HSPCs), the importance of TET2 in bone marrow mesenchymal stromal cells (BMSCs) remains unknown. In this study...

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Veröffentlicht in:Stem Cell Reports
Hauptverfasser: Li, Rong, Zhou, Yuan, Cao, Zeng, Liu, Lin, Wang, Jinhuan, Chen, Zizhen, Xing, Wen, Chen, Shi, Bai, Jie, Yuan, Weiping, Cheng, Tao, Xu, Mingjiang, Yang, Feng-Chun, Zhao, Zhigang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768963/
https://ncbi.nlm.nih.gov/pubmed/29290626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.11.019
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