A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy

C-to-U RNA editing of glycine receptors (GlyR) can play an important role in disease progression of temporal lobe epilepsy (TLE) as it may contribute in a neuron type-specific way to neuropsychiatric symptoms of the disease. It is therefore necessary to develop tools that allow identification of neu...

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Détails bibliographiques
Publié dans:Front Mol Neurosci
Auteurs principaux: Kankowski, Svenja, Förstera, Benjamin, Winkelmann, Aline, Knauff, Pina, Wanker, Erich E., You, Xintian A., Semtner, Marcus, Hetsch, Florian, Meier, Jochen C.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2018
Sujets:
Neuroscience
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768626/
https://ncbi.nlm.nih.gov/pubmed/29375302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00439
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