AAV-PHP.B-Mediated Global-Scale Expression in the Mouse Nervous System Enables GBA1 Gene Therapy for Wide Protection from Synucleinopathy

The lack of technology for direct global-scale targeting of the adult mouse nervous system has hindered research on brain processing and dysfunctions. Currently, gene transfer is normally achieved by intraparenchymal viral injections, but these injections target a restricted brain area. Herein, we d...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Ther
Egile Nagusiak: Morabito, Giuseppe, Giannelli, Serena G., Ordazzo, Gabriele, Bido, Simone, Castoldi, Valerio, Indrigo, Marzia, Cabassi, Tommaso, Cattaneo, Stefano, Luoni, Mirko, Cancellieri, Cinzia, Sessa, Alessandro, Bacigaluppi, Marco, Taverna, Stefano, Leocani, Letizia, Lanciego, José L., Broccoli, Vania
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Gene & Cell Therapy 2017
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768559/
https://ncbi.nlm.nih.gov/pubmed/28882452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.08.004
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