B Cell-Intrinsic Role for IRF5 in TLR9/BCR-Induced Human B Cell Activation, Proliferation, and Plasmablast Differentiation

Upon recognition of antigen, B cells undergo rapid proliferation followed by differentiation to specialized antibody secreting cells (ASCs). During this transition, B cells are reliant upon a multilayer transcription factor network to achieve a dramatic remodeling of the B cell transcriptional lands...

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Bibliographische Detailangaben
Veröffentlicht in:Front Immunol
Hauptverfasser: De, Saurav, Zhang, Baohong, Shih, Tiffany, Singh, Sukhwinder, Winkler, Aaron, Donnelly, Robert, Barnes, Betsy J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768180/
https://ncbi.nlm.nih.gov/pubmed/29367853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01938
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