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Src homology 2 domains enhance tyrosine phosphorylation in vivo by protecting binding sites in their target proteins from dephosphorylation

Phosphotyrosine (pTyr)-dependent signaling is critical for many cellular processes. It is highly dynamic, as signal output depends not only on phosphorylation and dephosphorylation rates but also on the rates of binding and dissociation of effectors containing phosphotyrosine-dependent binding modul...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Jadwin, Joshua A., Curran, Timothy G., Lafontaine, Adam T., White, Forest M., Mayer, Bruce J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767867/
https://ncbi.nlm.nih.gov/pubmed/29162725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.794412
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