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A subclass of serum anti-ZnT8 antibodies directed to the surface of live pancreatic β-cells

The islet-specific zinc transporter ZnT8 is a major self-antigen found in insulin granules of pancreatic β-cells. Frequent insulin secretion exposes ZnT8 to the cell surface, but the humoral antigenicity of the surface-displayed ZnT8 remains unknown. Here we show that a membrane-embedded human ZnT8...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Merriman, Chengfeng, Huang, Qiong, Gu, Wei, Yu, Liping, Fu, Dax
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767863/
https://ncbi.nlm.nih.gov/pubmed/29184000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000195
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