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A subclass of serum anti-ZnT8 antibodies directed to the surface of live pancreatic β-cells
The islet-specific zinc transporter ZnT8 is a major self-antigen found in insulin granules of pancreatic β-cells. Frequent insulin secretion exposes ZnT8 to the cell surface, but the humoral antigenicity of the surface-displayed ZnT8 remains unknown. Here we show that a membrane-embedded human ZnT8...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5767863/ https://ncbi.nlm.nih.gov/pubmed/29184000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000195 |
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