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Structure-guided engineering of the substrate specificity of a fungal β-glucuronidase toward triterpenoid saponins
Glycoside hydrolases (GHs) have attracted special attention in research aimed at modifying natural products by partial removal of sugar moieties to manipulate their solubility and efficacy. However, these modifications are challenging to control because the low substrate specificity of most GHs ofte...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5767852/ https://ncbi.nlm.nih.gov/pubmed/29146597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.801910 |
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