Targeted Serum Metabolite Profiling Identifies Metabolic Signatures in Patients with Alzheimer's Disease, Normal Pressure Hydrocephalus and Brain Tumor

Progression to AD is preceded by elevated levels of 2,4-dihydroxybutanoic acid (2,4-DHB), implicating hypoxia in early pathogenesis. Since hypoxia may play a role in multiple CNS disorders, we investigated serum metabolite profiles across three disorders, AD, Normal Pressure Hydrocephalus (NPH) and...

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Veröffentlicht in:Front Neurosci
Hauptverfasser: Orešič, Matej, Anderson, Gabriella, Mattila, Ismo, Manoucheri, Manoucher, Soininen, Hilkka, Hyötyläinen, Tuulia, Basignani, Cherlynn
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767271/
https://ncbi.nlm.nih.gov/pubmed/29375291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2017.00747
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