Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML

Bone marrow vascular niches sustain hematopoietic stem cells (HSCs) and are drastically remodeled in leukemia to support pathological functions. Acute myeloid leukemia (AML) cells produce angiogenic factors, which likely contribute to this remodeling, but anti-angiogenic therapies do not improve AML...

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書誌詳細
出版年:Cell Stem Cell
主要な著者: Duarte, Delfim, Hawkins, Edwin D., Akinduro, Olufolake, Ang, Heather, De Filippo, Katia, Kong, Isabella Y., Haltalli, Myriam, Ruivo, Nicola, Straszkowski, Lenny, Vervoort, Stephin J., McLean, Catriona, Weber, Tom S., Khorshed, Reema, Pirillo, Chiara, Wei, Andrew, Ramasamy, Saravana K., Kusumbe, Anjali P., Duffy, Ken, Adams, Ralf H., Purton, Louise E., Carlin, Leo M., Lo Celso, Cristina
フォーマット: Artigo
言語:Inglês
出版事項: Cell Press 2018
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766835/
https://ncbi.nlm.nih.gov/pubmed/29276143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.11.006
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