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Drug-Driven Phenotypic Convergence Supports Rational Treatment Strategies of Chronic Infections

Chronic Pseudomonas aeruginosa infections evade antibiotic therapy and are associated with mortality in cystic fibrosis (CF) patients. We find that in vitro resistance evolution of P. aeruginosa toward clinically relevant antibiotics leads to phenotypic convergence toward distinct states. These stat...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell
Prif Awduron: Imamovic, Lejla, Ellabaan, Mostafa Mostafa Hashim, Dantas Machado, Ana Manuel, Citterio, Linda, Wulff, Tune, Molin, Soren, Krogh Johansen, Helle, Sommer, Morten Otto Alexander
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cell Press 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766827/
https://ncbi.nlm.nih.gov/pubmed/29307490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.12.012
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