Polypharmacy through Phage Display: Selection of Glucagon and GLP-1 Receptor Co-agonists from a Phage-Displayed Peptide Library

A promising emerging area for the treatment of obesity and diabetes is combinatorial hormone therapy, where single-molecule peptides are rationally designed to integrate the complementary actions of multiple endogenous metabolically-related hormones. We describe here a proof-of-concept study on deve...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Demartis, Anna, Lahm, Armin, Tomei, Licia, Beghetto, Elisa, Di Biasio, Valentina, Orvieto, Federica, Frattolillo, Francesco, Carrington, Paul E., Mumick, Sheena, Hawes, Brian, Bianchi, Elisabetta, Palani, Anandan, Pessi, Antonello
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766609/
https://ncbi.nlm.nih.gov/pubmed/29330364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18494-5
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