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Targeting Insulin-Like Growth Factor-I and Extracellular Matrix Interactions in Melanoma Progression
Insulin-like growth factor (IGF)-I binds to the ECM protein vitronectin (VN) through IGF binding proteins (IGFBPs) to enhance proliferation and migration of skin keratinocytes and fibroblasts. Although evidence exists for the role of individual components of the complex (IGF-I, IGFBP-3 and VN), the...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5766529/ https://ncbi.nlm.nih.gov/pubmed/29330502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-19073-4 |
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