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Targeting Insulin-Like Growth Factor-I and Extracellular Matrix Interactions in Melanoma Progression

Insulin-like growth factor (IGF)-I binds to the ECM protein vitronectin (VN) through IGF binding proteins (IGFBPs) to enhance proliferation and migration of skin keratinocytes and fibroblasts. Although evidence exists for the role of individual components of the complex (IGF-I, IGFBP-3 and VN), the...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Murekatete, Berline, Shokoohmand, Ali, McGovern, Jacqui, Mohanty, Lipsa, Meinert, Christoph, Hollier, Brett G., Zippelius, Alfred, Upton, Zee, Kashyap, Abhishek S.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766529/
https://ncbi.nlm.nih.gov/pubmed/29330502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-19073-4
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