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Large-scale aggregation analysis of eukaryotic proteins reveals an involvement of intrinsically disordered regions in protein folding

A subset of the proteome is prone to aggregate formation, which is prevented by chaperones in the cell. To investigate whether the basic principle underlying the aggregation process is common in prokaryotes and eukaryotes, we conducted a large-scale aggregation analysis of ~500 cytosolic budding yea...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Uemura, Eri, Niwa, Tatsuya, Minami, Shintaro, Takemoto, Kazuhiro, Fukuchi, Satoshi, Machida, Kodai, Imataka, Hiroaki, Ueda, Takuya, Ota, Motonori, Taguchi, Hideki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766493/
https://ncbi.nlm.nih.gov/pubmed/29330519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18977-5
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