Patterns of Metastatic Spread and Mechanisms of Resistance to Crizotinib in ROS1-Positive Non–Small-Cell Lung Cancer

PURPOSE: The ROS1 tyrosine kinase is activated through ROS1 gene rearrangements in 1% to 2% of non–small-cell lung cancers (NSCLCs), which confer sensitivity to treatment with the anaplastic lymphoma kinase (ALK)/ROS1/mesenchymal-epithelial transition factor inhibitor crizotinib. Currently, insights...

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Bibliografische gegevens
Gepubliceerd in:JCO Precis Oncol
Hoofdauteurs: Gainor, Justin F., Tseng, Diane, Yoda, Satoshi, Dagogo-Jack, Ibiayi, Friboulet, Luc, Lin, Jessica J., Hubbeling, Harper G., Dardaei, Leila, Farago, Anna F., Schultz, Katherine R., Ferris, Lorin A., Piotrowska, Zofia, Hardwick, James, Huang, Donghui, Mino-Kenudson, Mari, Iafrate, A. John, Hata, Aaron N., Yeap, Beow Y., Shaw, Alice T.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Clinical Oncology 2017
Onderwerpen:
Original Reports
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766287/
https://ncbi.nlm.nih.gov/pubmed/29333528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.17.00063
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