NEAT1 Scaffolds RNA Binding Proteins and the Microprocessor to Globally Enhance Pri-miRNA Processing

MicroRNA biogenesis is known to be modulated by a variety of RNA binding proteins (RBPs), but in most cases, individual RBPs appear to influence the processing of a small subset of target miRNAs. We herein report that the RNA binding NONO/PSF heterodimer binds a large number of expressed pri-miRNAs...

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Publicado no:Nat Struct Mol Biol
Main Authors: Jiang, Li, Shao, Changwei, Wu, Qi-Jia, Chen, Geng, Zhou, Jie, Yang, Bo, Li, Hairi, Gou, Lan-Tao, Zhang, Yi, Wang, Yangming, Yeo, Gene W., Zhou, Yu, Fu, Xiang-Dong
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766049/
https://ncbi.nlm.nih.gov/pubmed/28846091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3455
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