Investigating methotrexate toxicity within a randomized double-blinded, placebo-controlled trial: Rationale and design of the Cardiovascular Inflammation Reduction Trial-Adverse Events (CIRT-AE) Study

BACKGROUND: The role of low dose methotrexate (LDM) in potential serious toxicities remains unclear despite its common use. Prior observational studies investigating LDM toxicity compared LDM to other active drugs. Prior placebo-controlled clinical trials of LDM in inflammatory conditions were not l...

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Publicado no:Semin Arthritis Rheum
Main Authors: Sparks, Jeffrey A., Barbhaiya, Medha, Karlson, Elizabeth W., Ritter, Susan Y., Raychaudhuri, Soumya, Corrigan, Cassandra C., Lu, Fengxin, Selhub, Jacob, Chasman, Daniel I., Paynter, Nina P., Ridker, Paul M., Solomon, Daniel H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765986/
https://ncbi.nlm.nih.gov/pubmed/28284844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semarthrit.2017.02.003
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