Pregnancy Increases Norbuprenorphine Clearance in Mice by Induction of Hepatic Glucuronidation

Norbuprenorphine (NBUP) is the major active metabolite of buprenorphine (BUP) that is commonly used to treat opiate addiction during pregnancy; it possesses 25% of BUP’s analgesic activity and 10 times BUP’s respiratory depression effect. To optimize BUP’s dosing regimen during pregnancy with better...

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Vydáno v:Drug Metab Dispos
Hlavní autoři: Liao, Michael Z., Gao, Chunying, Phillips, Brian R., Neradugomma, Naveen K., Han, Lyrialle W., Bhatt, Deepak Kumar, Prasad, Bhagwat, Shen, Danny D., Mao, Qingcheng
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765905/
https://ncbi.nlm.nih.gov/pubmed/29158248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.117.076745
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