Pregnancy Increases Norbuprenorphine Clearance in Mice by Induction of Hepatic Glucuronidation

Norbuprenorphine (NBUP) is the major active metabolite of buprenorphine (BUP) that is commonly used to treat opiate addiction during pregnancy; it possesses 25% of BUP’s analgesic activity and 10 times BUP’s respiratory depression effect. To optimize BUP’s dosing regimen during pregnancy with better...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Liao, Michael Z., Gao, Chunying, Phillips, Brian R., Neradugomma, Naveen K., Han, Lyrialle W., Bhatt, Deepak Kumar, Prasad, Bhagwat, Shen, Danny D., Mao, Qingcheng
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765905/
https://ncbi.nlm.nih.gov/pubmed/29158248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.117.076745
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