Exposure‐response relationship of certolizumab pegol induction and maintenance therapy in patients with Crohn's disease

BACKGROUND: Therapeutic drug monitoring may optimize therapy for Crohn's disease (CD). AIM: To use a population pharmacokinetic model that accounts for the time‐varying nature of covariates to simulate certolizumab pegol (CZP) concentrations to evaluate the exposure‐response relationship for CZ...

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Udgivet i:Aliment Pharmacol Ther
Main Authors: Vande Casteele, N., Feagan, B. G., Vermeire, S., Yassine, M., Coarse, J., Kosutic, G., Sandborn, W. J.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Certolizumab in Crohn's Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765392/
https://ncbi.nlm.nih.gov/pubmed/29159893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/apt.14421
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